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Malabsorption (insufficient absorption of vitamin B12in the intestine) through, Insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and isrequiredfor the absorption of vitamin B12), Diseases in the terminal segment of the ileum (part of the small intestine), e.g

Nov 2015;32(11):1575-88

If the proposed mechanism (gradual synaptic plasticity effects) is right, daily dosing might be needed for sustained effect

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CagriSema is filed T2D evidence : Tirzepatide has more extensive T2D trial data GI tolerability : CagriSema has higher overall GI event rates Conclusion# CagriSema and tirzepatide represent different strategies to the same goal: surpassing GLP-1-only weight loss

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