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Eight-week swimming exercise pre-conditioning attenuates one-time exhaustion exercise-induced MQC deficits in the heart of obese mice, increases PINK1, SIRT1, PGC-1, Mfn1, and Drp1 protein expression, decreases p62 and Cyt-c protein levels, promotes mitophagy, mitochondrial biogenesis, and mitochondrial fission/fusion homeostasis, which in turn downregulates Bax protein expression, increases Bcl-2 and Bcl-2/BAX levels, and inhibits cardiac apoptosis in obese mice (Pires et al., 2022)