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Patients with diabetes, pre-existing foot conditions, or those experiencing very rapid weight loss are at higher risk

The oral bioavailability of the pill may not be the same as with injectables, but the overall clinical efficacy indicates that it can reach sufficient systemic exposure to meet the clinical endpoint

This helps determine if youre a candidate and which medication and dose makes sense

DOI: 10.2147/CCID.S128339 Mischley LK, Lau RC, Shankland EG, et al

Mediators stimulating C-fibers vary: in dogs, pulmonary subtypes do not (but bronchial subtypes do) respond to histamine, and in other animal models, they do not respond to serotonin or adenosine

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