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Practical considerations often influence route selection beyond theoretical optimization

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High homocysteine levels are problematic because they have been linked to heart disease and atherosclerosis.32 In people who are deficient or have mutations in the enzymes that catalyze the production of glutathione from homocysteine, the methylation cycle will be under pressure to remove excess homocysteine

But the essential theory of commercial plasma collection is that the easiest and cheapest way to create a large base of recurring donors is to pay them

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