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The clinical data: exactly how much does retatrutide increase heart rate The most authoritative data comes from the phase 2 randomized controlled trial published in the New England Journal of Medicine (Jastreboff et al.)

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Lifestyle Support Matters More Than the Medication Alone No medication replaces healthy habits

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This may mean taking too little medicine, which can hamper weight loss, or too much, which may cause severe gastrointestinal side effects

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