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CJC-1295 also activates direct GH action on skeletal muscle (independent of hepatic IGF-1): skeletal muscle GHR expression (quantifiable by flow cytometry or western blot in human muscle biopsy) drives STAT5b-dependent IGF-1 autocrine synthesis, lipolysis via HSL phosphorylation (GH-direct, IGF-1-independent), and satellite cell GHR-STAT5b activation

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doi: 10.1210/jc.2006-1821 198

Direct Autocrine Action of Insulin on -Cells: does It Make Physiological Sense

Tirzepatide also comes from compounding pharmacies in multi-dose vials with various concentrations