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The ability of curcumin to down-regulate the expression of fibronectin, one of the ECM proteins, which is overexpressed in leiomyoma as compared to normal myometrium, has also been documented (Supriono et al., 2018) suggest the possible mechanism of curcumin in producing anti-uterine fibroid activity via reducing the ECM production, thus further study investigating the effects of curcumin on various ECM-related receptors and proteins in leiomyoma cells may be conducted

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If it continues, GERD can cause scarring and narrowing of the esophagus and increase a persons risk of esophageal cancer.Results show that people taking GLP-1 drugs were 27% more likely to develop GERD and 55% more likely to have GERD complications, when compared to people taking SGLT-2 inhibitors.More than 90% of GERD complications involved Barrett esophagus, in which acid damage changes the tissue lining of the esophagus and increases cancer risk, researchers noted.We also found that the risk for GERD was higher with long-acting GLP-1 (drug) use, researchers wrote.However, they noted that these findings need to be verified by studies involving other groups, including those taking GLP-1 drugs for obesity.There is limited evidence on the risk for GERD among patients with obesity who do not have type 2 diabetes, researchers wrote