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Ahmad, Zaheer, Ming Xie, Yongbao Wu, and Shuisheng Hou

Central serotonin and melanocortin pathways regulating energy homeostasis

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The research rationale established by NNMT-knockdown studies in diet-induced-obese mice is that inhibiting NNMT preserves intracellular NAD+ and SAM levels, which in adipocyte (fat-cell) models has been shown to suppress de novo lipogenesis