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in 2022, Martins & colleagues showed that women with overweight who experienced an average weight loss of 16% had a metabolic adaptation of approximately ~50kcal/day. Meaning, while metabolic adaptation does occur, its not likely the primary culprit of a stalled diet

It usually begins in the mid-40s, although timing varies widely, and can last for around four to eight years

Switching between GLP-1 medications as a reset strategy Not everyone wants to take a complete medication break

Less commonly, some patients who are taking other medications for diabetes may experience hypoglycemia, or very low blood sugar levels

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There have been reports of people developing skin problems after starting semaglutide