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Top-line results of the phase 2 trial demonstrated metopimazine led to a 40% reduction in the incidence of nausea and a 56% reduction in frequency of vomiting

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This setup produced opposite PA signal changes when GSH was reduced, allowing for specific and sensitive detection [96]

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While further research is required to translate these preclinical findings into clinical practice, the identification of the GLP-1R/PPARG/ACSL1 pathway provides a clear roadmap for future investigations into the intersection of metabolic drugs and cancer immunotherapy in the future

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