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Nudleman, E

244 Adverse effects have included gastrointestinal symptoms, dose limitations, and electrocardiographic abnormalities, such as prolonged QT intervals

Additionally, around 12% of oxygen used in mitochondrial metabolism produces free radicals, which can lead to oxidative stress and even DNA damage [2]

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Understanding these possibilities helps you monitor your routine more effectively

A non-canonical mechanism of Nrf2 activation by autophagy deficiency due to direct interaction between Keap1 and p62 has been recently proposed [56,57]