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While the precise reason for GLP-1 nausea is not yet clear, it is likely due to the delayed stomach emptying (gastroparesis) or eating too much of the wrong kinds of foods

And if you've had minimal success with other GLP-1 medications in the past, the dual-action of Tirzepatide might give you better results

More commonly, I see it in combination with iron deficiency and sometimes folate deficiency

Gastrointestinal manifestations of cystic fibrosis

In experimental systems, the combination is studied as a model for examining how complementary peptide signaling pathways influence tissue remodeling and cellular repair responses

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