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Their blood sugar gets really high

Muscle tissue has faster, more chaotic blood flow that can cause rapid, uneven medication absorption

222 Aside from the potential for systemic oxalosis, concern is also warranted because a pro-oxidant effect of high-dose vitamin C, either directly or through its effects on mobilization of iron, has been reported

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[1] [4] However, post-marketing surveillance and real-world patient experiences have prompted further investigation into potential psychological effects