Vrentzos, E., Ikonomidis, I., Pavlidis, G., Katogiannis, K., Korakas, E., Kountouri, A., Pliouta, L., Michalopoulou, E., Pelekanou, E., Boumpas, D., & Lambadiari, V
169,177,178 In a preliminary trial in 17 healthy reproductive-aged women, taking 4,000 mg of an omega-3 fatty acid supplement (providing 1,860 mg eicosapentaenoic acid [EPA] and 1,500 mg docosahexaenoic acid [DHA]) daily for one month led to reductions in levels of FSH, a hormonal marker of diminished ovarian reserve and early menopause, in normal weight, but not obese, participants
Hydrogen peroxide as a signaling molecule
It helps in transporting long-chain fatty acids into cells to be used as energy, assisting in weight management and enhancing exercise performance
Importantly, alongside the observed improvement in BBB function was an enhancement of antioxidant capacity, increased vascular endothelial growth factor and BDNF signalling (Cho and Roh, 2022)
Eur J Pharmacol 547:192199 Lindsay JR, Duffy NA, McKillop AM, Ardill J, O'Harte FP, Flatt PR, Bell PM (2005) Inhibition of dipeptidyl peptidase IV activity by oral metformin in type 2 diabetes
