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Indeed, MRP1 transports GS-conjugated anions like Leukotriene C 4 (LTC 4 ), a physiological substrate transported with a high affinity 4

Antonin Dvorak (1841-1904)

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NNMT inhibition with 5-Amino-1MQ reduced white adipose tissue mass by ~35% in diet-induced obese mouse models without suppressing food intake, suggesting energy expenditure modulation

They both exhibit greater lipophilicity and could penetrate cells with greater readiness while providing greater effect compared to other chelating substances that act extracellularly such as DMSA