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Jul-Aug 2013;19(4):406-418

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2.7% 2.7% OR 71 OUT OF 2,635 patients on LOVENOX /warfarin experienced DVT/PE 2.3% 2.3% OR 59 OUT OF 2,609 patients on ELIQUIS experienced DVT/PE In this study, bleeding events were also compared

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Crucially, the ROS generated during GSH degradation by CHAC1 may also cause further TP53 mutations, creating a vicious self-reinforcing cycle: CHAC1 activity promotes the very TP53 mutations that allow the tumor to exploit CHAC1s harmful effect for growth