During ischemia, oxygen deprivation suppresses critical metabolic pathways such as those involving fatty acids, ketone bodies, branched-chain amino acids (BCAAs), and glucose oxidation, drastically reducing ATP production
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While the FDA includes a boxed warning about potential thyroid cancer risk, clinical trials involving over 10,000 participants have not demonstrated increased thyroid nodule or cancer incidence in humans
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[51] : 695 Prostatic cancer typically occurs in the PZ
& Jamora, R
