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Although L-arginine supplements are generally considered safe, speak with a healthcare professional before taking them, especially if you: have an underlying health condition are taking medications are pregnant or nursing L-arginine may interact with certain medications, including: Blood-pressure-lowering medications: enalapril (Vasotec), losartan (Cozaar), amlodipine (Norvasc), furosemide (Lasix), etc

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This is based on the clinical trial design, which used fixed dosing across weight categories

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