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The $10 billion price rested on optimistic assumptions about Metseras future performance, estimating Pfizer would need to generate about $11 billion in revenue from the deal by 2040 nearly double Metseras current projections, Courtney Breen, an analyst at Bernstein, said

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Insufficient production of NO has been shown to be a significant factor in the development of chronic wounds such as diabetic foot ulcer (DFU), primarily due to resultant impaired antimicrobial activities 63,70

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