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It is safe for tirzepatide or semaglutide to go through the X-ray machine at TSA, but you can always request an alternative screening method

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Under pathological conditions such as calcium overload, higher ROS, ATP depletion, or ischemic injury, the mPTP can open transiently or persistently, leading to dissipation of the mitochondrial membrane potential, matrix swelling, and rupture of OMM [38,39,40,41]