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Guidelines NICE (UK), NHS MSK pathways, and British Society for Surgery of the Hand These typically recommend: Conservative management first, including: Activity modification NSAIDs Splinting (usually 26 weeks) RCT evidence: 2023 JAMA Network Open Systematic Review & Network Metaanalysis (30 RCTs, n=1,663) Findings: Corticosteroid injection + thumb spica splint = best outcomes for pain and function

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1 Endotoxin limits should be calculated using the maximum drug dose intended for intravenous (IV) administration

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Research Focus : Safety & Metabolism (Non-Clinical) Title : Safety and Metabolism of AOD9604, a Novel Nutraceutical Ingredient for Improved Metabolic Health (J Endocrinol Metab, Vol 4, No 3, June 2014) Authors : Margret I

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