These outcomes suggest semaglutide provides dual benefit: weight loss plus direct metabolic remodeling that favors cardiovascular health
The liver is the main site of IGF-I production and is regulated by GH
However, better also depends on your cardiovascular health, insurance coverage, tolerance, and whether you prefer an oral option (which only Wegovy offers)
The FDA also recommends examining hard clinical endpoints such hepatic decompensations, transplant free survival, and all-cause mortality, although these results are not necessarily needed prior to drug approval given the long length of follow up potentially required
The absence of generic semaglutide has significant implications for medication access and affordability
Researchers suggested that this difference was likely due to altered drug processing in the body, rather than more aggressive disease alone, raising the possibility that weight normalization could improve treatment effectiveness, says Ali
