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works best as an add-on inside a structured plan Semaglutide (GLP-1 medication) What it is: Prescription GLP-1 medication Primary effect: Appetite regulation and satiety Evidence for weight loss: Strong What to know: FDA-approved options exist for chronic weight management

Factors that reduce the risk of weight regain include: Consistent protein intake Strength or resistance training Structured meal timing Adequate sleep Stress management Addressing insulin resistance Gradually tapering instead of stopping abruptly Regain is a biological response, not a failure

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Scenario analyses were also carried out in two additional subpopulations: (i) patients with BMI 35 kg/m 2 and (ii) patients with BMI 30 kg/m 2 who presented at least one CV event (MI, stroke or peripheral arterial disease)