Discovery of efficacious Pseudomonas aeruginosa -targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic/pharmacodynamic model
10.4239/wjd.v15.i2.287 86 WuF.YangL.HangK.LaursenM.WuL.HanG
The FDA approved a pill version of Wegovy on Dec
Outcome studies show that GLP-1 medicines reduce rates of complications associated with T2D and/or obesity, including cardiovascular diseases, metabolic dysfunctionassociated liver diseases, chronic kidney disease, osteoarthritis, and obstructive sleep apnea (Figure 1)
Future clinical studies should account for baseline choline status, microbiome profiles, genetic polymorphism in choline metabolic pathways, and organ-specific outcomes to define optimal strategies for leveraging the use of modulating choline availability and metabolism in personalized therapeutic interventions
These early clinical results reinforce the potential of our approach to go beyond slowing the hair loss process and directly drive hair follicle regeneration, said Christina Weng, Chief Medical Officer of Pelage Pharmaceuticals, in the press release
