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Chanarin, 2000)

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However, these synthetic versions are engineered to resist breakdown by the DPP-4 enzyme that rapidly degrades natural GLP-1, remain active in the bloodstream for much longer periods (days to weeks versus minutes for natural GLP-1), and achieve blood concentrations far higher than the body naturally produces

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Groop PH, Cooper ME, Perkovic V, Hocher B, Kanasaki K, Haneda M, Schernthaner G, Sharma K, Stanton RC, Toto R, Cescutti J, Gordat M, Meinicke T, Koitka-Weber A, Thiemann S, von Eynatten M