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10.1186/s12958-018-0343-0 68 XuJ.LeiY.ZhangX.LiJ.LinQ.WuX.et al (2025)

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In this context, metformin, a well-established initial treatment (Maruthur et al., 2016), distinguishes itself for its hypoglycemic ability and its broader effects such as enhanced endothelial function, reducing oxidative stress and insulin resistance, improving lipid profiles and managing fat redistribution (Rojas and Gomes, 2013)

Individuals with diabetes have lower GSH levels compared to control subjects (Samiec et al., 1998

However, postprandial hyperinsulinemia may exist before fasting hyperinsulinemia develops (31)