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Evolving Concepts of Rheumatoid Arthritis

Simultaneous overactivation of Wnt/-catenin and TGF signalling by miR-128-3p confers chemoresistance-associated metastasis in NSCLC

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First, enhanced bioavailability: nanocarriers (e.g., liposomes and polymeric nanoparticles) improve solubility and stability of poorly water-soluble drugs like OXY and colchicine, ensuring consistent therapeutic plasma levels (Peng et al., 2023

In certain embodiments, any controlled release otic formulation described herein increases the exposure of a therapeutic agent and increases the length of time that the concentration of a therapeutic agent is above C min by about 30%, about 40%, about 50%, about 60%, about 70%, about 80% or about 90% compared to a formulation or composition that is not a controlled release otic formulation or composition