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GLP-1 side effects All of the GLP-1s went through an extensive clinical review and approval process and are considered generally safe medications

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Although GLP-1RAs seem to have a beneficial influence in reversing many maladaptive brain changes relevant to depression, it should be remembered that at the same time, they are also known to mediate some unfavorable processes such as activation of the HPA axis and intensification of anxiety-like behavior in some animal studies