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Many treatments approved for T2DM treatment such as sulphonylureas and thiazolidinediones (TZDs) improve glucose metabolism but have the unwanted side effect of causing weight gain (Thule and Umpierrez, 2014) and (Kahn et al., 2006
The pharmacology: why splitting changes the side-effect curve Tirzepatide (the active ingredient in Zepbound) has a half-life of about 5 days
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This is part of how Ozempic works, but it can feel more pronounced in the first couple of days
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Br J Sports Med
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