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While these medications had impactful weight loss outcomes, with mean weight reduction in trials ranging from 7 to 10% [3,4,5], they lacked substantial evidence of improvement in cardiovascular outcomes
Thyroid dysfunction, hormonal imbalances, new medications with weight-promoting side effects, insulin resistance progression, and water retention from various causes can all masquerade as medication tolerance
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These are less common but can cause upper gut bleeding and melena
