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However, ICIs can cause immune-related side effects (irAEs) by impairing peripheral immunological tolerance, and the endocrine glands are among the organs most frequently impacted

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The rash usually worsens significantly during the first one to two weeks before any improvement appears

Available from: Bossart M, Wagner M, Elvert R, Evers A, Hbschle T, Kloeckener T, et al