If this resonates, read our deep dive on gaining weight on tirzepatide
DPP-4 Inhibitors as therapeutic modulators of immune cell function and associated cardiovascular and renal insulin resistance in obesity and diabetes
Hollowell JG, Staehling NW, Flanders WD, et al
Spironolactone Class * Potassium-sparing diuretic * Aldosterone (mineralocorticoid) receptor antagonist Mechanism of Action Spironolactone blocks aldosterone receptors in the distal convoluted tubule and collecting duct, resulting in: * Increased sodium and water excretion * Reduced potassium excretion (potassium retention) * Reduced cardiac and vascular remodeling in heart failure Indications * Heart failure with reduced ejection fraction (HFrEF) * Resistant hypertension * Primary hyperaldosteronism (Conn syndrome) * Ascites due to liver cirrhosis * Edema associated with heart failure or nephrotic syndrome * Polycystic ovary syndrome (PCOS) for hirsutism * Prevention of hypokalemia Dosage Adults * Heart failure: 12.525 mg once daily, titrated as needed * Ascites: 100400 mg daily * Hypertension: 25100 mg daily Adverse Effects Common * Hyperkalemia * Nausea * Dizziness * Fatigue Endocrine Effects * Gynecomastia * Breast tenderness * Erectile dysfunction * Decreased libido * Menstrual irregularities Contraindications * Hyperkalemia * Severe renal impairment * Addison disease * Hypersensitivity to spironolactone Drug Interactions * ACE inhibitors * ARBs * Potassium supplements * Other potassium-sparing diuretics These combinations increase the risk of hyperkalemia
Ive also tried the infusions and cant wait for the next, the difference in how I felt was noticeable
By now, you've probably heard the word "semaglutide" more than a few times from your provider, a friend, a social media feed, or a late-night news segment
