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The exception worth mentioning is that very high-dose folic acid can mask vitamin B12 deficiency on laboratory testing (by correcting macrocytic anaemia even if B12 itself remains low)

Intestinal mucosal (membrane-bound or intracellular) enzymes break down NAD(P) niacin equivalents in the diet into NAM.[2225] This process occurs mostly in the small intestine, where NAD + is first converted by pyrophosphatases to nicotinamide mononucleotide (NMN)

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What differentiates IV infusions from oral vitamin supplements

51, 52, 53 In the small intestine, GPBAR1/TGR5 activation could favorably modulate insulin sensitivity and glucose metabolism through stimulating the secretion of the incretin hormone glucagon-like peptide-1 (GLP-1) by ileal enteroendocrine L cells

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