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ROS Scavenging and Gene Regulation: Oxidative stress upregulates the Microphthalmia-associated Transcription Factor (MITF), which acts as the primary on-switch for melanin production [5]

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In OC treatment, the natural compound -sitosterol (SIT) has demonstrated the potential to strengthen the interaction between NRF2 and Keap1, promoting NRF2s ubiquitin-dependent degradation and subsequently diminishing the transcriptional activation of downstream antioxidant genes

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In high-risk individuals, metformin is also used to delay the onset of type 2 diabetes