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The second study with 426 patients randomly assigned to TAK-875, placebo, or glimepiride treatment groups showed significant reductions in HbA1c levels from baseline in the TAK-875 (6.25 to 50 mg) and glimepiride (4 mg) treatment groups compared with the placebo group at week 12 [60]

10.1016/j.immuni.2013.02.003 78 KarakaH

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doi: 10.1093/ajcn/80.6.1689S

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Berberine, a plant alkaloid studied for blood sugar control, is increasingly combined with GLP-1 receptor agonists like semaglutide by patients seeking enhanced metabolic benefits