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Neuron-specific sterol 24-hydroxylase (CYP46A1), which is highly expressed in the cerebral cortex, hippocampus, amygdala, caudate nucleus, putamen, and frontal lobe, catalyzes the conversion of cholesterol into the more soluble oxysterol 24(S)-hydroxycholesterol, which is subsequently metabolized to chenodeoxycholic acid (CDCA) [79]

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