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Support for this hypothesis comes from the finding that, in ovariectomized rats, estradiol replacement enhances peripheral GLP-1 induced suppression on food intake (199, 200)

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Due to the extensive range of QCT targets, we focused on identifying key targets with potentially crucial roles or central significance

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Horn described the drug as one that could position it to be the 'metformin' of obesity, capturing hopes that a pill could be easier and cheaper to scale than todays injectable GLP1 drugs