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In large randomized trials of FDA-approved branded semaglutide, once-weekly treatment alongside lifestyle intervention produced substantial average weight loss over 68 weeks (Wilding et al., 2021), with continued treatment supporting weight maintenance (Rubino et al., 2021)

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These drugs, known as glucagon-like peptide-1 receptor agonists or GLP-1 medications, have gained attention for their role in helping people manage type 2 diabetes, and more recently, for their weight loss benefits

19 The SOD and GPx enzyme activity may be able to give positive supportive evidence to the surgeon, thereby allowing an objective tipping point for an exploratory laparotomy

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