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However, lawsuits accuse Novo Nordisk of not adequately warning users of the following possible side effects: Vision loss or changes Gastroparesis (stomach paralysis) Neuropathy with gastroparesis Intestinal blockage (often requiring surgery to repair) Cyclical vomiting Pancreatic cancer Necrotizing pancreatitis Esophageal injury with surgery Blood clots Has Rybelsus Harmed You

This discrepancy between results in animal models and clinical studies may partly be due to myocardial insulin resistance in severely failing hearts and the use of beta-blockers [21]

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The most frequent adverse effects are gastrointestinal: nausea (R11.0), vomiting (R11.1), diarrhoea (K52.9/R19.7), and constipation (K59.0)