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Molecular basis of the KEAP1-NRF2 Signaling pathway

Published clinical observations describe collagen depletion and muscle loss as accelerating the ageing process in ways that manifest within months of initiating therapy

However, the study lacked a placebo control, limiting interpretation (Kalamkar et al., Antioxidants, 2022) [55]

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10.3390/ijms21207623 179 NouriF.BabaeeM.PeydayeshP.EsmailyH.RaeissadatS

This multi-axis neuroendocrine regulatory profile positions DSIP as a broad hypothalamic-pituitary axis modulator, not merely a sleep-specific peptide, and makes it a research tool for studying the neuroendocrine consequences of altered sleep homeostasis and circadian rhythm disruption