Eur Cytokine Netw 15(2):99104 Saha S, Gonzalez J, Rosenfeld G, Keiser H, Peeva E (2009) Prolactin alters the mechanisms of B cell tolerance induction
Possible Side Effects / Considerations Mild gastrointestinal symptoms such as nausea, bloating, or diarrhea (often most noticeable during early weeks)
It is used as an anti-aging therapy and to treat obesity and other metabolic disorders
A pragmatic trial period might be 812 weeks, during which weight, waist circumference, and any gastrointestinal symptoms should be monitored
The approval, for patients with MASH with moderate to advanced liver scarring, was based on results of the Phase III MAESTRO-NASH trial, where the MASH resolved in 25.9% of patients who received an 80-mg dose of Rezdiffra and 29.9% of those taking 100 mg, with no worsening of fibrosis
Full elimination takes 5-6 weeks, but appetite restoration happens progressively throughout this period rather than suddenly