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Deuxiemement, une interaction avec le systeme opioidergique endogene : le DSIP modifie la reactivite aux agonistes opioides sans etre lui-meme opioide, ce qui a ete interprete comme une action allosterique ou indirecte

You must drink 2-3L of water per day for the duration of your treatment plan

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Gastrointestinal infections with gram negative bacteria can also cause a leaky gut, and Lipopolysaccharides (LPS) (bacterial toxins) produced by gram negative bacteria, can translocate through the intestinal barrier and travel to joints

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they may also cause irritability