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A pharmacokinetic study was conducted in rats following oral administration of mildronate at doses of 40160 mg/kg

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Maintaining stable temperature and low humidity conditions helps to preserve the materials chemical stability and prevent moisture absorption

We simulated hyperhomocysteinemia artificially (that is, we treated it as a parameter in the simulations), increasing Hcy levels to around 400% of the physiological reference value

Given that sensory or gastrointestinal adverse effects, such as dysgeusia and persistent nausea, can impair nutritional intake and lead to early treatment discontinuation (particularly in vulnerable populations) future research must incorporate rigorous sensory testing, larger and more diverse cohorts, and adherence-related outcomes to clarify how incretin therapies influence taste perception and long-term eating behavior (153, 157, 161)

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