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While there is some existing research on berberine as a standalone supplement, the evidence doesn't support the idea that it works as effectively as a prescription GLP-1 medication , and studies on the transdermal delivery method (absorbing supplements through the skin) for these ingredients are lacking

Patients should seek urgent medical attention if they experience signs of a severe allergic reaction (such as widespread rash, facial or tongue swelling, or breathing difficulties) or extensive skin reactions

[1] Serious adverse events should be reported to the FDA MedWatch program

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Berberine-Induced Glucagon-Like Peptide-1 and its Mechanism for Controlling Type 2 Diabetes

The theoretical mechanism involves transdermal absorption of GLP-1 analogs or related compounds through the skin's stratum corneum into systemic circulation