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GLP-1 (glucagon-like peptide-1) is a naturally occurring gut hormone released in response to food intake

Studie Jastreboff et al

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After adding either the cGASSTING pathway inhibitor C-176 or GLP-1RAs, the cGAS-STING signaling pathway was inhibited effectively accompanied with suppression of chondrocyte ferroptosis, inflammatory factor expression, and osteophyte formation on articular surfaces, and enhancement of cartilage repair, reinforcing a causal link between cGASSTING activation and chondrocyte ferroptosis in RA

Its actions on GLP-1 and GIP receptors promote delayed gastric emptying and appetite control, offering a comprehensive approach to obesity research distinct from older GLP-1 agonists.