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Many may need to continue taking GLP-1 medications in order to maintain their weight loss and health goals The doses of medication may stay the same or may be reduced to find the lowest effective dose that maintains weight and health Lifestyle and behavioural changes in the maintenance phase are crucial Any reduction or stopping of GLP-1 medication should be done under medical supervision, gradually Monitor weight and appetite vigilantly Many people will find that they can use a reduced dose of GLP-1 medication once they have achieved their target BMI

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Efficacy Retatrutide has been impressive in clinical trials

By contrast, exenatide and roflumilast were associated with greater uncertainty, with 95% credible intervals crossing the null

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