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Careful assessment of headache characteristics, timing relative to medication initiation or dose changes, and comparison to the patient's baseline headache pattern helps determine causality

Bioorthogonal conjugation of azide-incorporated antibodies can be achieved by using strained cyclooctyne-functionalized linkers that do not require a cytotoxic, oxidative copper catalyst (Fig

While the benefits resulting from chronic stimulation of the cerebellar cortex were significant [67, 131, 297,298,299,300,301,302,303,304,305,306], it may be easiest to focus invasive stimulation approaches (such as DBS) on the deep cerebellar nuclei (or on the pathways emanating from them), given the substantial topographic spread of motor representations along the cerebellar cortex

Employed to improve binding efficiency between the target molecules and ligands by overcoming steric hindrances

Proc Natl Acad Sci 79(2):345349 Ma Y, Huang Y, Yan L, Gao M, Liu D (2013) Synthetic FXR agonist GW4064 prevents diet-induced hepatic steatosis and insulin resistance