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Further analysis indicated that among the 19 overgrown bacterial families, 12 possessed the urease gene ( Alteromonadaceae , Clostridiaceae , Cellulomonadaceae , Enterobacteriaceae , Dermabacteraceae , Halomonadaceae , Micrococcaceae , Moraxellaceae , Methylococcaceae , Pseudomonadaceae , Polyangiaceae , and Xanthomonadaceae ), 5 harbored the uricase gene ( Dermabacteraceae , Cellulomonadaceae , Xanthomonadaceae , Micrococcaceae , and Polyangiaceae ) producing ammonia that is harmful to the intestinal epithelium, and 3 expressed the tryptophanase gene necessary for the conversion of tryptophan into indole, which is then metabolized by the liver into uremic toxins ( Enterobacteriaceae , Clostridiaceae , and Verrucomicrobiaceae ) (Wong et al., 2014)
And GiActin is an actin within the extracellular space
4,14 Management strategies Reducing histamine intake involves eliminating aged cheeses, cured meats, fresh, canned, or fermented oily fish, fermented vegetables, citrus, strawberries, tomatoes, avocados, chocolate, nuts, wine, and beer from the diet
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For type 2 diabetes, Ozempic and Mounjaro are usually on Tier 2 or Tier 3 with prior authorization
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