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Current guideline-recommended therapies for DPN focus on symptom relief rather than modifying the disease

Sirago, G., et al., Growth hormone secretagogues hexarelin and JMV2894 protect skeletal muscle from mitochondrial damages in a rat model of cisplatin-induced cachexia

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The potential value of combining these therapies lies in addressing overlapping cardiorenal and metabolic risk pathways as available evidence for dual therapy in HF populations remains limited and is derived largely from subgroup analyses, observational studies, and extrapolation from diabetes or obesity trials rather than dedicated HF randomized trials [24, 25, 27, 30, 50]