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The new blockbuster obesity drugs, made famous by Ozempic, are collectively known as GLP-1 agonists, for the hormone they mimic in the body: glucagon-like peptide 1

For the highest dose group (12 mg), this is what the titration schedule looked like: Weeks 1-4 : 2 mg once weekly Weeks 5-8 : 4 mg once weekly Weeks 9-12 : 8 mg once weekly Weeks 13 onward : 12 mg once weekly What phase 3 trials show so far: Testing long-term dosing of retatrutide In more recent phase 3 trials , the doses used are a bit different, but the overall structure still follows that same gradual, step-by-step pattern

The main difference lies in how they work in the body: Semaglutide : Targets the GLP-1 receptor only, enhancing the bodys natural fullness signals and slowing digestion

It also helps hair grow thicker and denser by waking up the stem cells in your hair follicles

There are more similarities than differences between the work done in companies and academia, and both are equally valid in my mind

Why Retatrutide Is Mechanistically Distinct Retatrutide is the first triple receptor agonist in human clinical trials in the GLP-1 class